Weight loss, particularly when using drugs like Wegovy and Ozempic, often leads to a loss of muscle mass, which impacts metabolic health, mobility, and injury risk. New research suggests that combining aerobic exercise with a calorie deficit might not be detrimental to muscles and could even have positive effects. A study involving ten fit young men found that exercising during a severe energy deficit did not negatively impact muscle function, though further research is needed to fully understand the molecular responses.