Oprah Winfrey shared her decades-long struggle with weight, explaining in a CBS News interview that obesity is a medical condition, not a failure of willpower. She detailed her experience of repeated weight loss and regain, attributing it to the body's natural 'set point' defended by genetics. Winfrey expressed joy in her current ability to maintain a comfortable weight, a significant shift after years of public scrutiny and personal battles with dieting and exercise.