San Francisco 49ers' Pro Bowl left tackle Trent Williams and receiver Ricky Pearsall missed practice Wednesday due to hamstring and knee injuries, respectively, casting doubt on their availability for the upcoming playoff game against the Philadelphia Eagles. Coach Kyle Shanahan expressed hope for their return Thursday but noted players can play without practice. The offense struggled without them last week, impacting the running game and deep passing. Linebacker Dee Winters and defensive lineman Keion White also missed practice, while linebacker Tatum Bethune was placed on injured reserve and Eric Kendricks was signed to the roster.