NASA Administrator Jared Isaacman stated that the U.S. aims to return to the moon during a potential second Trump term, viewing the moon as a base for an "orbital economy." Plans include establishing a permanent lunar base, utilizing nuclear energy for deep space missions, and expanding commercial activity. The Artemis program, with Artemis II and III missions involving SpaceX's lunar lander, is seen as crucial for affordable and frequent lunar travel, paving the way for Mars missions.