The first quarter of the 21st century has been marked by seismic global shifts, including challenges to American hegemony by a resurgent China, the rise of authoritarian democracies, and technological revolutions like AI. These changes have impacted global polity, economy, environment, science, and culture. Emerging markets like India have ascended, while crises like the dotcom bust and the global financial meltdown have occurred. The article emphasizes harmonizing these changes with civilizational ethos.