The San Francisco 49ers are set to host the Seattle Seahawks in their season finale, with the NFC's top seed and the division title at stake. The 49ers, coming off a high-scoring win, feature quarterback Brock Purdy who has had recent success with multiple touchdowns. The Seahawks, who won their last game with quarterback Sam Darnold, face a tough challenge against the 49ers' strong run defense. Both teams have had turnover issues, and key offensive linemen are listed as questionable or out for the Seahawks.